Aim Oral health in pregnant and lactating women can affect maternal and child health. Dental treatments in this period should not have adverse effects on maternal and child health. This study was conducted to investigate the last-year dental students’ knowledge of the prescription of analgesics and antibiotics for pregnant and lactating mothers in Isfahan city, Iran. Methods A total of 104 last-year dental students of Khorasgan Islamic Azad University and Isfahan University of Medical Sciences were recruited in this descriptive-analytical study. They completed a 16-item questionnaire on the prescription of analgesics and antibiotics for pregnant and lactating mothers. Data were analyzed by SPSS (Version 22) statistical software(t-test). Results The total mean score of students’ knowledge was 9.02±1.91. The highest level of knowledge about the safest analgesic (acetaminophen) was reported for the pregnant patients so that 100% of them had correct information in this regard. Further, the lowest level of knowledge was found for the use of dexamethasone during lactation, as only 10.6% of respondents were able to provide a correct response in this regard. Conclusion The dental students had average knowledge about the prescription of antibiotics and analgesics for pregnant and lactating patients. To prevent the possible risks for these patients, further information should be provided to dental students.

Aldeídos e cetonas são intermediários importantes principalmente na construção de esqueletos carbônicos. A oxidação de álcoois é tão importante que um grande número de métodos e reagentes foi relatado com essa proposta. Reagentes N-halo são amplamente utilizados em síntese inorgânica e como continuação do nosso interesse na aplicação de compostos N-halo em síntese inorgânica, dibromo dimetilidantoína (DBDMH) e dicloro dimetilidantoína (DCDMH) foram usados na oxidação de álcoois e nosso trabalho em andamento está baseado no desenvolvimento de protocolos de oxidação altamente eficientes. Observamos a oxidação de álcoois secundários com quantidades estequiométricas de DBDMH e DCDMH em condições livre de solventes, na faixa de temperatura de 70-80 ºC.

Aldehydes and ketones are important intermediates, especially for the construction of carbon-skeletons. The oxidation of alcohols is so important that a large number of methods and reagents have been reported for this purpose. N-halo reagents are widely used in organic synthesis and as a continuation of our interest in the application of N-halo compounds in organic synthesis, dibromo dimethylhydantoin (DBDMH) and dichloro dimethylhydantoin (DCDMH) were used for the oxidation of alcohols and our ongoing work on development of highly efficient oxidation protocols. We observed the oxidation of secondary alcohols with stoichiometric amounts of DBDMH and DCDMH under solvent-free conditions in the range of temperature 70-80 ºC.

Sistemas de liberação de fármacos baseados em conjugados polímero-fármaco fornecem um tratamento melhorado com menor toxidade ou efeitos colaterais e são usados no tratamento de diferentes doenças. Conjugados de poli(estireno-alt-anidrido maleico) (PSMA) biodegradável, com agentes terapêuticos tais como cloridrato de amantadina, amlopidina, gabapentina, zonisamida e mesalamina, foram gerados pela formação de ligações de amidas dos fármacos amino que reagiram com os grupos anidridos do PSMA. As quantidades de fármacos covalentemente conjugados foram determinadas por ressonância magnética nuclear (NMR) de¹ H, e a taxa de liberação in vitro em solução tampão (pH 1.3) foi estudada à temperatura do corpo (37 ºC). Em estudos de cinética, modelos de dissolução diferentes foram examinados a fim de se obter dados de liberação do fármaco e os dados coletados se ajustaram bem a equação de Korsmeyer-Peppas, revelando um mecanismo de difusão Fickaniano dominante na liberação do fármaco em condições in vitro.

Drug delivery systems based on polymer-drug conjugates give an improved treatment with lower toxicity or side effects and be used for the treatment of different diseases. Conjugates of biodegradable poly(styrene-alt-maleic anhydride) (PSMA), with a therapeutic agents such as amantadine hydrochloride, amlodipine, gabapentin, zonisamide and mesalamine, were afforded by the formation of the amide bonds of the amino drugs that reacted with the PSMA anhydride groups. The amounts of covalently conjugated drugs were determined by a¹ H NMR spectroscopic method, and the in vitro release rate in buffer solution (pH 1.3) was studied at body temperature 37 ºC. In kinetic studies, different dissolution models were examined to obtain drug release data and the collected data were well-fitted to the Korsmeyer-Peppas equation, revealing a dominant Fickian diffusion mechanism for drug release under the in vitro conditions.